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Category:Translation softwareMany humans and animals have allergic reactions which consist of an over-production of IgE antibody. IgE is the only class of antibody which reacts with surface membrane-bound antigen. It is not only used for defense against pathogenic microorganisms, but is also involved in a number of pathological responses. It is known that IgE has four different antigen-binding sites on its Fc portion which are designated as CH1-CH4. For example, high affinity IgE antibody is known to be directed against the CH2 domain.
Because IgE is the only known antibody which reacts with surface membrane-bound antigens, IgE plays a major role in allergic responses. IgE mediates acute allergic reactions including atopic dermatitis, hay fever and asthma. This form of the disease and many of the symptoms can be controlled by oral or inhaled administration of anti-IgE antibody.
Anti-IgE antibody may be administered in monoclonal form or polyclonal form. The administration of monoclonal IgE was first reported by R. Kirsner et al. in Immunological Reviews 61:155, 1984. The intravenous injection of anti-human IgE resulted in a maximum serum anti-IgE antibody level after 3 days which persisted for approximately 8 days.
Similarly, small amounts of anti-human IgE were seen in pulmonary lavage after inhalation of monoclonal IgE antibody. See R. Choulika et al., Allergol Immunopathol. 7:53, 1980 and Langerman et al., Am. Rev. Respir Dis. 127:928, 1982. The inhalation of bronchodilators, however, may have had some effect on the results.
Borrow et al. determined the lung retention of monoclonal IgE antibodies. Borrow et al., Eur. J. Immunol. 15:260, 1985. They found that 4-5% of the administered labeled antibody was retained after 18
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