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In the present study, we sought to determine if estrogen contributes to the expression of Ca2+-sensing receptor (CaSR) and the store-operated Ca2+ entry (SOCE) channel (ORAI1) proteins in streptozotocin (STZ)-induced diabetic rats. Thirty-six adult rats were divided into three groups: nondiabetic rats, sham-operated rats, and STZ-induced diabetic rats. Diabetic rats were given 17beta-estradiol (E2) or vehicle (0.1% ethanol) for 2 months. The protein levels of CaSR and ORAI1 in CaSR-positive vascular smooth muscle cells in the aortic media were significantly reduced in diabetic rats compared with nondiabetic rats. The administration of 17beta-estradiol ameliorated the decrease in the expression of CaSR and ORAI1 in diabetic rats. This study suggests that estrogen may be a potential therapeutic agent for increasing Ca2+-dependent Ca2+ signaling in diabetic vascular smooth muscle cells.The 49ers’ Jimmy Garoppolo isn’t your average pick for the Pro Bowl, but he’s unlikely to make the NFL’s All-Decade team. No one has a more secure place on the 2014 Associated Press All-Pro team, but his peers have chosen 49ers linebacker NaVorro Bowman as the NFL’s best middle linebacker.

Garoppolo is one of 18 quarterbacks to make the four-player AP All-Pro team, a group that includes Detroit’s Matthew Stafford and New England’s Tom Brady. It’s another testament to Garoppolo’s toughness. There hasn’t been a quarterback in the history of the league with that kind of physical damage to his body and still be able to perform at a high level.

Garoppolo has avoided injury in his first three seasons. He hasn’t been the quarterback of the future, but he’s been a

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